SLC9A1

Échangeur sodium-hydrogène 1
Structures disponibles PDB Recherche d'orthologue : PDBe RCSB Identifiants PDB 1Y4E, 2BEC, 2E30, 2KBV, 2L0E, 2MDF, 2YGG
Identifiants
Alias	SLC9A1
IDs externes	OMIM: 107310 MGI: 102462 HomoloGene: 20660 GeneCards: SLC9A1
Position du gène (humain) Chr. Chromosome 1 humain Locus 1p36.11 Début 27,098,809 bp Fin 27,166,981 bp
Position du gène (souris) Chr. Chromosome 4 (souris) Locus 4 D2.3|4 66.25 cM Début 133,097,017 bp Fin 133,151,013 bp
Expression génique Bgee Humain Souris (orthologue) Fortement exprimé dans parotide mucosa of transverse colon ovocyte placenta corps de l'estomac stromal cell of endometrium pylore putamen mucosa of urinary bladder nasal epithelium Fortement exprimé dans epithelium of stomach zygote articulation talo-crurale antre du pylore secondary oocyte mucous cell of stomach gastrula granulocyte Caduque basale lèvre Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire protein-macromolecule adaptor activity calcium-dependent protein binding phosphatidylinositol-4,5-bisphosphate binding antiporter activity solute:proton antiporter activity sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential fixation de la calmoduline liaison protéique molecular adaptor activity protein phosphatase 2B binding sodium:proton antiporter activity potassium:proton antiporter activity Composant cellulaire cytoplasme membrane focal adhesion T-tubule mitochondrie perinuclear region of cytoplasm cation-transporting ATPase complex surface cellulaire apical plasma membrane réticulum endoplasmique radeau lipidique exosome lamellipode integral component of membrane intercalated disc membrane plasmique nucléoplasme membrane du réticulum endoplasmique integral component of plasma membrane basolateral plasma membrane sarcolemma Processus biologique regulation of cardiac muscle contraction by calcium ion signaling regulation of sensory perception of pain positive regulation of the force of heart contraction positive regulation of cardiac muscle hypertrophy cellular response to epinephrine stimulus positive regulation of action potential cellular response to mechanical stimulus maintenance of cell polarity cellular response to hypoxia positive regulation of mitochondrial membrane permeability response to muscle stretch proton transmembrane transport cellular sodium ion homeostasis cardiac muscle cell differentiation ion transport positive regulation of cell growth cellular response to insulin stimulus regulation of focal adhesion assembly regulation of cardiac muscle cell membrane potential response to acidic pH différenciation cellulaire regulation of the force of heart contraction cellular response to organic cyclic compound cellular response to acidic pH cation transport negative regulation of apoptotic process regulation of the force of heart contraction by cardiac conduction regulation of pH cardiac muscle cell contraction neuron death hyaluronan catabolic process response to organic cyclic compound sodium ion transport regulation of intracellular pH positive regulation of intracellular signal transduction regulation of stress fiber assembly positive regulation of calcineurin-NFAT signaling cascade protein complex oligomerization sodium ion import across plasma membrane positive regulation of apoptotic process cellular response to antibiotic positive regulation of calcium:sodium antiporter activity migration cellulaire positive regulation of transcription by RNA polymerase II cellular response to electrical stimulus potassium ion transmembrane transport transport transmembranaire transport cellular response to cold sodium ion export across plasma membrane anion transmembrane transport sodium ion transmembrane transport Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 6548 20544 Ensembl ENSG00000090020 ENSMUSG00000028854 UniProt P19634 Q61165 RefSeq (mRNA) NM_003047 NM_016981 NM_001358455 RefSeq (protéine) NP_003038 NP_058677 NP_001345384 Localisation (UCSC) Chr 1: 27.1 – 27.17 Mb Chr 4: 133.1 – 133.15 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

SLC9A1 est un gène situé sur le chromosome 1 humain.

Maladies liées

• Syndrome d'ataxie progressive-surdité autosomique récessive